• Issue

    Alzheimer's & Dementia: Volume 19, Issue 2

    383-740
    February 2023
Previous Issue|Next Issue
Export Citation(s)

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 383-389
  • First Published: 15 February 2023

FEATURED ARTICLES

Open Access

The small HDL particle hypothesis of Alzheimer's disease

Ashley E. Martinez,  Gali Weissberger,  Zsuzsanna Kuklenyik,  Xulei He,  Cristiana Meuret,  Trusha Parekh,  Jon C. Rees,  Bryan A. Parks,  Michael S. Gardner,  Sarah M. King,  Timothy S. Collier,  Michael G. Harrington,  Melanie D. Sweeney,  Xinhui Wang,  Berislav V. Zlokovic,  Elizabeth Joe,  Daniel A. Nation,  Lon S. Schneider,  Helena C. Chui,  John R. Barr,  S. Duke Han,  Ronald M. Krauss,  Hussein N. Yassine, 
  • Pages: 391-404
  • First Published: 13 April 2022
Open Access

Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration

Gabrielle Zuniga,  Simon Levy,  Paulino Ramirez,  Jasmine De Mange,  Elias Gonzalez,  Maria Gamez,  Bess Frost, 
  • Pages: 405-420
  • First Published: 13 April 2022
Open Access

COVID-19 breakthrough infections and hospitalizations among vaccinated patients with dementia in the United States between December 2020 and August 2021

Lindsey Wang,  Pamela B. Davis,  David C. Kaelber,  Rong Xu, 
  • Pages: 421-432
  • First Published: 13 April 2022
Open Access

The Collaborative Approach for Asian Americans and Pacific Islanders Research and Education (CARE): A recruitment registry for Alzheimer's disease and related dementias, aging, and caregiver-related research

Van M. Ta Park,  Oanh L. Meyer,  Janice Y. Tsoh,  Alka M. Kanaya,  Marian Tzuang,  Bora Nam,  Quyen Vuong,  Joon Bang,  Ladson Hinton,  Dolores Gallagher-Thompson,  Joshua D. Grill, 
  • Pages: 433-443
  • First Published: 14 April 2022

Quantification of amyloid beta and tau PET without a structural MRI

Susan M. Landau,  Tyler J. Ward,  Alice Murphy,  Leonardo Iaccarino,  Theresa M. Harrison,  Renaud La Joie,  Suzanne Baker,  Robert A. Koeppe,  William J. Jagust,  for the Alzheimer's Disease Neuroimaging Initiative , 
  • Pages: 444-455
  • First Published: 16 April 2022

A near-infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer's disease

Li Quan,  Ines Moreno-Gonzalez,  Zhigang Xie,  Nazaret Gamez,  Laura Vegas-Gomez,  Qinyong Song,  Jianhua Gu,  Wenhai Lin,  Ruben Gomez-Gutierrez,  Tianfu Wu, 
  • Pages: 456-466
  • First Published: 18 April 2022
A near-infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer's disease

In the present study, a novel near-infrared fluorescent probe (NB) was designed and synthesized to specifically bind a phenylalanine dipeptide (FF) motif of β-amyloid (Aβ). It is important to note that the NB probe not only predominantly recognizes oligomeric Aβ but also inhibits Aβ  self-assembly through π-π interaction between NB and FF. This mechanism of action holds great promise in the early diagnosis of AD and may provide a novel therapeutic strategy to combat AD and other types of amyloidosis.

Open Access

Hypertension, a dementia polygenic risk score, APOE genotype, and incident dementia

Thomas J. Littlejohns,  Jennifer A. Collister,  Xiaonan Liu,  Lei Clifton,  Neo M. Tapela,  David J. Hunter, 
  • Pages: 467-476
  • First Published: 19 April 2022
Open Access

Dementia risk predictions from German claims data using methods of machine learning

Constantin Reinke,  Gabriele Doblhammer,  Matthias Schmid,  Thomas Welchowski, 
  • Pages: 477-486
  • First Published: 22 April 2022
Open Access

Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers

Frank Jessen,  Steffen Wolfsgruber,  Luca Kleineindam,  Annika Spottke,  Slawek Altenstein,  Claudia Bartels,  Moritz Berger,  Frederic Brosseron,  Marcel Daamen,  Martin Dichgans,  Laura Dobisch,  Michael Ewers,  Friederike Fenski,  Klaus Fliessbach,  Silka D. Freiesleben,  Wenzel Glanz,  Doreen Görß,  Selim Gürsel,  Daniel Janowitz,  Ingo Kilimann,  Xenia Kobeleva,  Andrea Lohse,  Franziska Maier,  Coraline Metzger,  Matthias Munk,  Lukas Preis,  Carolin Sanzenbacher,  Eike Spruth,  Boris Rauchmann,  Ruth Vukovich,  Renat Yakupov,  Anne-Sophie Weyrauch,  Gabriel Ziegler,  Matthias Schmid,  Christoph Laske,  Robert Perneczky,  Anja Schneider,  Jens Wiltfang,  Stefan Teipel,  Katharina Bürger,  Josef Priller,  Oliver Peters,  Alfredo Ramirez,  Henning Boecker,  Michael T. Heneka,  Michael Wagner,  Emrah Düzel, 
  • Pages: 487-497
  • First Published: 22 April 2022

Everyday function profiles in prodromal stages of MCI: Prospective cohort study

Joe Verghese,  Pierfilippo De Sanctis,  Emmeline Ayers, 
  • Pages: 498-506
  • First Published: 26 April 2022

Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimer's disease and related dementias

Song-Yi Park,  Veronica Wendy Setiawan,  Lon R. White,  Anna H. Wu,  Iona Cheng,  Christopher A. Haiman,  Lynne R. Wilkens,  Loїc Le Marchand,  Unhee Lim, 
  • Pages: 507-517
  • First Published: 27 April 2022
Open Access

Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease

Rui Chang,  Eugenia Trushina,  Kuixi Zhu,  Syed Shujaat Ali Zaidi,  Branden M. Lau,  Alexandra Kueider-Paisley,  Sara Moein,  Qianying He,  Melissa L. Alamprese,  Barbora Vagnerova,  Andrew Tang,  Ramachandran Vijayan,  Yanyun Liu,  Andrew J. Saykin,  Roberta D. Brinton,  Rima Kaddurah-Daouk,  for the Alzheimer's Disease Neuroimaging Initiative† and the Alzheimer's Disease Metabolomics Consortium , 
  • Pages: 518-531
  • First Published: 28 April 2022
Open Access

Longitudinal changes in cerebral blood flow and their relation with cognitive decline in patients with dementia: Current knowledge and future directions

Ralf W.J. Weijs,  Daria A. Shkredova,  Anna C.M. Brekelmans,  Dick H.J. Thijssen,  Jurgen A.H.R. Claassen, 
  • Pages: 532-548
  • First Published: 29 April 2022
Open Access

Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study

Erin O. Semmens,  Cindy S. Leary,  Annette L. Fitzpatrick,  Sindana D. Ilango,  Christina Park,  Claire E. Adam,  Steven T. DeKosky,  Oscar Lopez,  Anjum Hajat,  Joel D. Kaufman, 
  • Pages: 549-559
  • First Published: 18 April 2022

Education, neighborhood environment, and cognitive decline: Findings from two prospective cohort studies of older adults in China

Yingzhe Wang,  Yanfeng Jiang,  Wanqing Wu,  Kelin Xu,  Qianhua Zhao,  Ziyi Tan,  Xiaoniu Liang,  Min Fan,  Zhenxu Xiao,  Li Zheng,  Saineng Ding,  Qiang Dong,  Zhen Hong,  Li Jin,  Xingdong Chen,  Ding Ding,  Mei Cui, 
  • Pages: 560-568
  • First Published: 31 May 2022

Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: Relationship to markers of vascular and Alzheimer's pathology

Zixuan Lin,  Chantelle Lim,  Dengrong Jiang,  Anja Soldan,  Corinne Pettigrew,  Kumiko Oishi,  Yuxin Zhu,  Abhay Moghekar,  Peiying Liu,  Marilyn Albert,  Hanzhang Lu, 
  • Pages: 569-577
  • First Published: 06 July 2022
Open Access

Cumulative loneliness and subsequent memory function and rate of decline among adults aged ≥50 in the United States, 1996 to 2016: Cumulative loneliness and memory aging in the US

Xuexin Yu,  Ashly C. Westrick,  Lindsay C. Kobayashi, 
  • Pages: 578-588
  • First Published: 03 August 2022

Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults

Yi Dong,  Yuanjing Li,  Keke Liu,  Xiaolei Han,  Rui Liu,  Yifei Ren,  Lin Cong,  Qinghua Zhang,  Tingting Hou,  Lin Song,  Shi Tang,  Lin Shi,  Yishan Luo,  Grégoria Kalpouzos,  Erika J. Laukka,  Bengt Winblad,  Yongxiang Wang,  Yifeng Du,  Chengxuan Qiu, 
  • Pages: 589-601
  • First Published: 15 September 2022

Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations

Jorge J. Llibre-Guerra,  Jing Li,  Yuting Qian,  Juan de Jesús Llibre-Rodriguez,  Ivonne Z. Jiménez-Velázquez,  Daisy Acosta,  Aquiles Salas,  Juan Carlos Llibre-Guerra,  Adolfo Valvuerdi,  Amal Harrati,  Jordan Weiss,  Mao-Mei Liu,  William H. Dow, 
  • Pages: 602-610
  • First Published: 04 June 2022

Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets

Jairo Ramos,  Laura J. Caywood,  Michael B. Prough,  Jason E. Clouse,  Sharlene D. Herington,  Susan H. Slifer,  M. Denise Fuzzell,  Sarada L. Fuzzell,  Sherri D. Hochstetler,  Kristy L. Miskimen,  Leighanne R. Main,  Michael D. Osterman,  Andrew F. Zaman,  Patrice L. Whitehead,  Larry D. Adams,  Renee A. Laux,  Yeunjoo E. Song,  Tatiana M. Foroud,  Richard P. Mayeux,  Peter St. George-Hyslop,  Paula K. Ogrocki,  Alan J. Lerner,  Jeffery M. Vance,  Michael L. Cuccaro,  Jonathan L. Haines,  Margaret A. Pericak-Vance,  William K. Scott, 
  • Pages: 611-620
  • First Published: 01 May 2022

Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort

Debora Melo Van Lent,  Hannah Gokingco,  Meghan I. Short,  Changzheng Yuan,  Paul F. Jacques,  José R. Romero,  Charles S. DeCarli,  Alexa S. Beiser,  Sudha Seshadri,  Jayandra J. Himali,  Mini E. Jacob, 
  • Pages: 621-631
  • First Published: 06 May 2022
Open Access

Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease

Jonathan Vöglein,  Nicolai Franzmeier,  John C. Morris,  Marianne Dieterich,  Eric McDade,  Mikael Simons,  Oliver Preische,  Anna Hofmann,  Jason Hassenstab,  Tammie L. Benzinger,  Anne Fagan,  James M. Noble,  Sarah B. Berman,  Neill R. Graff-Radford,  Bernardino Ghetti,  Martin R. Farlow,  Jasmeer P. Chhatwal,  Stephen Salloway,  Chengjie Xiong,  Celeste M Karch,  Nigel Cairns,  Richard J. Perrin,  Gregory Day,  Ralph Martins,  Raquel Sanchez-Valle,  Hiroshi Mori,  Hiroyuki Shimada,  Takeshi Ikeuchi,  Kazushi Suzuki,  Peter R. Schofield,  Colin L Masters,  Alison Goate,  Virginia Buckles,  Nick C. Fox,  Patricio Chrem,  Ricardo Allegri,  John M. Ringman,  Igor Yakushev,  Christoph Laske,  Mathias Jucker,  Günter Höglinger,  Randall J. Bateman,  Adrian Danek,  Johannes Levin,  for the Dominantly Inherited Alzheimer Network , 
  • Pages: 632-645
  • First Published: 24 May 2022
Open Access

Subcortical brain structures and the risk of dementia in the Rotterdam Study

Isabelle F. van der Velpen,  Vanja Vlasov,  Tavia E. Evans,  Mohammad Kamran Ikram,  Boris A. Gutman,  Gennady V. Roshchupkin,  Hieab H. Adams,  Meike W. Vernooij,  Mohammad Arfan Ikram, 
  • Pages: 646-657
  • First Published: 28 May 2022
Open Access

Global estimates on the number of persons across the Alzheimer's disease continuum

Anders Gustavsson,  Nicholas Norton,  Thomas Fast,  Lutz Frölich,  Jean Georges,  Drew Holzapfel,  Tunahan Kirabali,  Pierre Krolak-Salmon,  Paolo M. Rossini,  Maria Teresa Ferretti,  Lydia Lanman,  Antonella Santuccione Chadha,  Wiesje M. van der Flier, 
  • Pages: 658-670
  • First Published: 02 June 2022

REVIEW ARTICLE

Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers

Ashley Carey,  Silvia Fossati, 
  • Pages: 671-695
  • First Published: 19 November 2022

PERSPECTIVES

Open Access

Recommendations to address key recruitment challenges of Alzheimer's disease clinical trials

Jessica B. Langbaum,  Julie Zissimopoulos,  Rhoda Au,  Niranjan Bose,  Chris J. Edgar,  Evan Ehrenberg,  Howard Fillit,  Carl V. Hill,  Lynne Hughes,  Michael Irizarry,  Sarah Kremen,  Darius Lakdawalla,  Nancy Lynn,  Kristina Malzbender,  Tetsuyuki Maruyama,  Holly A. Massett,  Deep Patel,  Desi Peneva,  Eric M. Reiman,  Klaus Romero,  Carol Routledge,  Michael W. Weiner,  Stacie Weninger,  Paul S. Aisen, 
  • Pages: 696-707
  • First Published: 10 August 2022
Open Access

Why a clinical trial is as good as its outcome measure: A framework for the selection and use of cognitive outcome measures for clinical trials of Alzheimer's disease

Roos J. Jutten,  Kathryn V. Papp,  Suzanne Hendrix,  Noel Ellison,  Jessica B. Langbaum,  Michael C. Donohue,  Jason Hassenstab,  Paul Maruff,  Dorene M. Rentz,  John Harrison,  Jeffrey Cummings,  Philip Scheltens,  Sietske A. M. Sikkes, 
  • Pages: 708-720
  • First Published: 10 September 2022
Open Access

Biomarkers for dementia in Latin American countries: Gaps and opportunities

Mario A. Parra,  Paulina Orellana,  Tomas Leon,  Cabello G. Victoria,  Fernando Henriquez,  Rodrigo Gomez,  Constanza Avalos,  Andres Damian,  Andrea Slachevsky,  Agustin Ibañez,  Henrik Zetterberg,  Betty M. Tijms,  Jennifer S. Yokoyama,  Stefanie D. Piña-Escudero,  J. Nicholas Cochran,  Diana L. Matallana,  Daisy Acosta,  Ricardo Allegri,  Bianca P. Arias-Suárez,  Bernardo Barra,  Maria Isabel Behrens,  Sonia M. D. Brucki,  Geraldo Busatto,  Paulo Caramelli,  Sheila Castro-Suarez,  Valeria Contreras,  Nilton Custodio,  Sergio Dansilio,  Myriam De la Cruz-Puebla,  Leonardo Cruz de Souza,  Monica M. Diaz,  Lissette Duque,  Gonzalo A. Farías,  Sergio T. Ferreira,  Nahuel Magrath Guimet,  Ana Kmaid,  David Lira,  Francisco Lopera,  Beatriz Mar Meza,  Eliane C. Miotto,  Ricardo Nitrini,  Alberto Nuñez,  Santiago O'Neill,  John Ochoa,  Maritza Pintado-Caipa,  Elisa de Paula França Resende,  Shannon Risacher,  Luz Angela Rojas,  Valentina Sabaj,  Lucas Schilling,  Allis F. Sellek,  Ana Sosa,  Leonel T. Takada,  Antonio L. Teixeira,  Martha Unaucho-Pilalumbo,  Claudia Duran-Aniotz, 
  • Pages: 721-735
  • First Published: 13 September 2022

LETTER

Open Access

Frontotemporal dementia associated with intrathecal antibodies against axon initial segments

Dominique Endres,  Andrea Schlump,  Kathrin Nickel,  Benjamin Berger,  Kimon Runge,  Thomas Lange,  Katharina Domschke,  Horst Urbach,  Nils Venhoff,  Philipp T. Meyer,  Joachim Brumberg,  Harald Prüss,  Ludger Tebartz van Elst, 
  • Pages: 736-739
  • First Published: 10 September 2022

ASSOCIATION UPDATE

Apply now to the Alzheimer's Association Interdisciplinary Summer Research Institute

  • Page: 740
  • First Published: February 2023