Volume 15, Issue 12 p. 1507-1515
Featured Article

Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results

Hector M. González

Corresponding Author

Hector M. González

Department of Neurosciences, Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, San Diego, CA, USA

Denotes shared first authorship in which both authors contributed equally to the manuscript.

Corresponding author. Tel.: (858) 534-5361.

E-mail address: [email protected]

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Wassim Tarraf

Wassim Tarraf

Department of Healthcare Sciences, Wayne State University, Institute of Gerontology, Detroit, MI, USA

Denotes shared first authorship in which both authors contributed equally to the manuscript.

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Neil Schneiderman

Neil Schneiderman

Department of Psychology, University of Miami, Miami, FL, USA

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Myriam Fornage

Myriam Fornage

University of Texas Health Science Center, Houston, TX, USA

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Priscilla M. Vásquez

Priscilla M. Vásquez

Department of Neurosciences, Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, San Diego, CA, USA

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Donglin Zeng

Donglin Zeng

Department of Biostatistics, University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA

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Marston Youngblood

Marston Youngblood

Department of Biostatistics, University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA

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Linda C. Gallo

Linda C. Gallo

Department of Psychology, San Diego State University, San Diego, CA, USA

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Martha L. Daviglus

Martha L. Daviglus

Institute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA

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Richard B. Lipton

Richard B. Lipton

Albert Einstein, College of Medicine, New York, NY, USA

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Robert Kaplan

Robert Kaplan

Albert Einstein, College of Medicine, New York, NY, USA

Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle WA, USA

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Alberto R. Ramos

Alberto R. Ramos

Department of Neurology, University of Miami, Miami, FL, USA

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Melissa Lamar

Melissa Lamar

Institute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA

Department of Psychiatry and Behavioral Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA

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Sonia Thomas

Sonia Thomas

RTI International, Research Triangle Park, NC, USA

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Albert Chai

Albert Chai

Department of Neurosciences, Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, San Diego, CA, USA

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Charles DeCarli

Charles DeCarli

Department of Neurology, Alzheimer's Disease Center, UC Davis, Sacramento, CA, USA

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First published: 18 November 2019
Citations: 49
Funding/Support: This work is supported by the National Institute on Aging (R01AG048642, RF1AG054548, RF1AG061022, and R21AG056952). Dr. González also receives additional support from P30AG005131 and P30AG059299. The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution-Office of Dietary Supplements.
Role of Funding Source: This work was supported by the National Institute on Aging and National Heart, Lung, and Blood Institute. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
Financial Disclosures: The authors report no conflicts of interest that could inappropriately influence, or be perceived to influence, this work.

Abstract

Introduction

We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos.

Methods

Middle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50–86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging–Alzheimer's Association diagnostic criteria.

Results

The overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI.

Discussion

MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.