Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years

Corresponding Author

Kevin A. Matthews

[email protected]

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, USA

Corresponding author. Tel.: +1 7704888124; Fax: +1 7704885965.

E-mail address: [email protected]

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Wei Xu,

Wei Xu

Department of Geography, University of Wisconsin-Milwaukee, Milwaukee, WI, USA

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Anne H. Gaglioti,

Anne H. Gaglioti

National Center for Primary Care, Department of Family Medicine, Morehouse School of Medicine, Atlanta, GA, USA

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James B. Holt,

James B. Holt

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, USA

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Janet B. Croft,

Janet B. Croft

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, USA

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Dominic Mack,

Dominic Mack

National Center for Primary Care, Department of Family Medicine, Morehouse School of Medicine, Atlanta, GA, USA

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Lisa C. McGuire,

Lisa C. McGuire

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, USA

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Kevin A. Matthews,

Corresponding Author

Kevin A. Matthews

[email protected]

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, USA

Corresponding author. Tel.: +1 7704888124; Fax: +1 7704885965.

E-mail address: [email protected]

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Wei Xu,

Wei Xu

Department of Geography, University of Wisconsin-Milwaukee, Milwaukee, WI, USA

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Anne H. Gaglioti,

Anne H. Gaglioti

National Center for Primary Care, Department of Family Medicine, Morehouse School of Medicine, Atlanta, GA, USA

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James B. Holt,

James B. Holt

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, USA

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Janet B. Croft,

Janet B. Croft

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, USA

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Dominic Mack,

Dominic Mack

National Center for Primary Care, Department of Family Medicine, Morehouse School of Medicine, Atlanta, GA, USA

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Lisa C. McGuire,

Lisa C. McGuire

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, USA

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First published: 19 September 2018

https://doi.org/10.1016/j.jalz.2018.06.3063

Citations: 753

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Abstract

Introduction

Alzheimer's disease and related dementias (ADRD) cause a high burden of morbidity and mortality in the United States. Age, race, and ethnicity are important risk factors for ADRD.

Methods

We estimated the future US burden of ADRD by age, sex, and race and ethnicity by applying subgroup-specific prevalence among Medicare Fee-for-Service beneficiaries aged ≥65 years in 2014 to subgroup-specific population estimates for 2014 and population projection data from the United States Census Bureau for 2015 to 2060.

Results

The burden of ADRD in 2014 was an estimated 5.0 million adults aged ≥65 years or 1.6% of the population, and there are significant disparities in ADRD prevalence among population subgroups defined by race and ethnicity. ADRD burden will double to 3.3% by 2060 when 13.9 million Americans are projected to have the disease.

Discussion

These estimates can be used to guide planning and interventions related to caring for the ADRD population and supporting caregivers.

Supporting Information

References

[1]2016 Alzheimer's disease facts and figures. Alzheimers Dement. 12: 2016; 459–509
10.1016/j.jalz.2016.03.001
PubMedGoogle Scholar
[2]R Brookmeyer, DA Evans, L Hebert, KM Langa, SG Heeringa, BL Plassman, et al. National estimates of the prevalence of Alzheimer's disease in the United States. Alzheimers Dement. 7: 2011; 61–73
10.1016/j.jalz.2010.11.007
PubMedWeb of Science®Google Scholar
[3]LE Hebert, J Weuve, PA Scherr, DA Evans. Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology. 80: 2013; 1778–1783
10.1212/WNL.0b013e31828726f5
PubMedWeb of Science®Google Scholar
[4]WA Rocca, RC Petersen, DS Knopman, LE Hebert, DA Evans, KS Hall, et al. Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States. Alzheimers Dement. 7: 2011; 80–93
10.1016/j.jalz.2010.11.002
PubMedWeb of Science®Google Scholar
[5]R Brookmeyer, N Abdalla, CH Kawas, MM Corrada. Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States. Alzheimer's Demen. 14: 2018; 121–129
10.1016/j.jalz.2017.10.009
PubMedWeb of Science®Google Scholar
[6] The Healthy Brain Initiative: The Public Health Road Map for State and National Partnerships, 2013–2018. 2013; Alzheimer's Association: Chicago, IL
Google Scholar
[7]Mirel LB, Wheatcroft G, Parker JD, Makuc D. Health Characteristics of Medicare Traditional Fee-for-Service and Medicare Advantage enrollees: 1999-2004 National Health and Nutrition Examination Survey linked to 2007 Medicare Data. (US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, 2012).
Google Scholar
[8]E Byhoff, JA Harris, JZ Ayanian. Characteristics of decedents in Medicare Advantage and traditional Medicare. JAMA Intern Med. 176: 2016; 1020–1023
10.1001/jamainternmed.2016.2266
PubMedWeb of Science®Google Scholar
[9]EA Miller, SL Decker, JD Parker. Characteristics of Medicare advantage and Fee-for-Service (FFS) beneficiaries upon enrollment in Medicare at Age 65. J Ambul Care Manag. 39: 2016; 231–241
10.1097/JAC.0000000000000107
PubMedWeb of Science®Google Scholar
[10]G Jacobson, A Damico, T Neuman, M Gold. Medicare Advantage 2015 Spotlight: Enrollment Market Update, Available at:http://kff.org/medicare/issue-brief/medicare-advantage-2015-spotlight-enrollment-market-update/ 2015, Accessed November 2017
Google Scholar
[11]DH Taylor Jr, T Østbye, KM Langa, D Weir, BL Plassman. The accuracy of Medicare claims as an epidemiological tool: The case of dementia revisited. J Alzheimers Dis. 17: 2009; 807
10.3233/JAD-2009-1099
PubMedWeb of Science®Google Scholar
[12]BL Plassman, KM Langa, GG Fisher, SG Heeringa, DR Weir, MB Ofstedal, et al. Prevalence of dementia in the United States: The aging, demographics, and memory study. Neuroepidemiology. 29: 2007; 125–132
10.1159/000109998
CASPubMedWeb of Science®Google Scholar
[13]Ortman JM, Velkoff VA, Hogan H. An Aging Nation: The Older Population in the United States. (United States Census Bureau, Economics and Statistics Administration, US Department of Commerce, 2014).
Google Scholar
[14]S Colby, J Ortman. Projections of the size and composition of the US population: 2014 to 2060 (Current Population Reports, P25-1143). 2017; US Census Bureau: Washington, DC, Accessed November 2017
Google Scholar
[15]R Bernstein. Census Bureau projections show a slower growing, older, more diverse nation a half century from now(Press Release, CB12-243)2015; US Census Bureau: Washington, DC, Accessed March 2016
Google Scholar
[16]RA Goodman, KA Lochner, M Thambisetty, TS Wingo, SF Posner, SM Ling. Prevalence of dementia subtypes in United States Medicare Fee-for-Service (FFS) beneficiaries, 2011–2013. Alzheimers Dement. 13: 2017; 28–37
10.1016/j.jalz.2016.04.002
PubMedWeb of Science®Google Scholar
[17]K Steenland, FC Goldstein, A Levey, W Wharton. A meta-analysis of Alzheimer's disease incidence and prevalence comparing African-Americans and Caucasians. J Alzheimer's Dis. 50: 2015; 71–76
10.3233/JAD-150778
PubMedWeb of Science®Google Scholar
[18]ER Mayeda, MM Glymour, CP Quesenberry, RA Whitmer. Inequalities in dementia incidence between six racial and ethnic groups over 14 years. Alzheimer's Demen. 12: 2016; 216–224
10.1016/j.jalz.2015.12.007
PubMedWeb of Science®Google Scholar
[19]R Samper-Ternent, YF Kuo, LA Ray, KJ Ottenbacher, KS Markides, S Al Snih. Prevalence of health conditions and predictors of mortality in oldest old Mexican Americans and non-Hispanic whites. J Am Med Directors Assoc. 13: 2012; 254–259
10.1016/j.jamda.2010.07.010
PubMedWeb of Science®Google Scholar
[20]MN Haan, DM Mungas, HM Gonzalez, TA Ortiz, A Acharya, WJ Jagust. Prevalence of dementia in older Latinos: The influence of type 2 diabetes mellitus, stroke and genetic factors. J Am Geriatr Soc. 51: 2003; 169–177
10.1046/j.1532-5415.2003.51054.x
PubMedWeb of Science®Google Scholar
[21]BJ Gurland, DE Wilder, R Lantigua, Y Stern, J Chen, EH Killeffer, et al. Rates of dementia in three ethnoracial groups. Int J Geriatr Psychiatry. 14: 1999; 481–493
10.1002/(SICI)1099-1166(199906)14:6<481::AID-GPS959>3.0.CO;2-5
CASPubMedWeb of Science®Google Scholar
[22]PC Clark, NG Kutner, FC Goldstein, S Peterson-Hazen, V Garner, R Zhang, et al. Impediments to timely diagnosis of Alzheimer's disease in African Americans. J Am Geriatr Soc. 53: 2005; 2012–2017
10.1111/j.1532-5415.2005.53569.x
PubMedWeb of Science®Google Scholar
[23]LJ Fitten, F Ortiz, M Pontón. Frequency of Alzheimer's disease and other dementias in a community outreach sample of Hispanics. J Am Geriatr Soc. 49: 2001; 1301–1308
10.1046/j.1532-5415.2001.49257.x
CASPubMedWeb of Science®Google Scholar
[24]A Solomon, F Mangialasche, E Richard, S Andrieu, DA Bennett, M Breteler, et al. Advances in the prevention of Alzheimer's disease and dementia. J Intern Med. 275: 2014; 229–250
10.1111/joim.12178
CASPubMedWeb of Science®Google Scholar
[25] Medicare Beneficiary Characteristics. 2014; Centers for Medicare and Medicaid Services: Baltimore, MD
Google Scholar
[26] Unpublished tabular data from the Office of Enterprise Data and Analytics. 2016; Centers for Medicare and Medicaid Services: Baltimore, MD
Google Scholar
[27]R Newcomer, T Clay, JS Luxenberg, RH Miller. Misclassification and selection bias when identifying Alzheimer's disease solely from Medicare claims records. J Am Geriatr Soc. 47: 1999; 215–219
10.1111/j.1532-5415.1999.tb04580.x
CASPubMedWeb of Science®Google Scholar
[28]T Erkinjuntti, T Østbye, R Steenhuis, V Hachinski. The effect of different diagnostic criteria on the prevalence of dementia. N Engl J Med. 337: 1997; 1667–1674
10.1056/NEJM199712043372306
CASPubMedWeb of Science®Google Scholar
[29]AL Sosa-Ortiz, I Acosta-Castillo, MJ Prince. Epidemiology of dementias and Alzheimer's disease. Arch Med Res. 43: 2012; 600–608
10.1016/j.arcmed.2012.11.003
PubMedWeb of Science®Google Scholar
[30] US Department of Health and Human Services. National Plan to Address Alzheimer's Disease, Available at:https://aspe.hhs.gov/national-plan-address-alzheimer%E2%80%99s-disease-2015-update 2016, Accessed July 2018
Google Scholar
[31]CB Cordell, S Borson, M Boustani, J Chodosh, D Reuben, J Verghese, et al. Alzheimer's Association recommendations for operationalizing the detection of cognitive impairment during the Medicare Annual Wellness Visit in a primary care setting. Alzheimer's Demen. 9: 2013; 141–150
10.1016/j.jalz.2012.09.011
PubMedWeb of Science®Google Scholar
[32]BE Hamilton, JA Martin, MJK Osterman, AK Driscoll, LM Roseen. Births: Provisional Data for 2016. (Vital Statistics Rapid Release; No 2). 2017; National Center for Health Statistics: Bethesda, MD
Google Scholar
[33]Older American 2012: Key Indicators of Well-Being. Washington, DC: Federal Interagency Forum on Aging-Related Statistics. US Government Printing Office; 2012.
Google Scholar
[34]D Redfoot, L Feinberg, A Houser. The Aging of the Baby Boom and the Growing Care Gap: A Look at Future Declines in the Availability of Family Caregivers. 2013; AARP Public Policy Institute: Washington, DC
Google Scholar
[35]PP Vitaliano, J Zhang, JM Scanlan. Is caregiving hazardous to one's physical health? A meta-analysis. Psychol Bull. 129: 2003; 946
10.1037/0033-2909.129.6.946
PubMedWeb of Science®Google Scholar
[36]S Sörensen, P Duberstein, D Gill, M Pinquart. Dementia care: Mental health effects, intervention strategies, and clinical implications. Lancet Neurol. 5: 2006; 961–973
10.1016/S1474-4422(06)70599-3
PubMedWeb of Science®Google Scholar
[37]R Schulz, SR Beach. Caregiving as a risk factor for mortality: The Caregiver Health Effects Study. JAMA. 282: 1999; 2215–2219
10.1001/jama.282.23.2215
CASPubMedWeb of Science®Google Scholar
[38]Revisions to payment policies under the physician fee schedule and other revisions to Part B for CY 2017. Fed Regist. 2016: 2016; 80170
Google Scholar
[39]MD Douglas, DE Dawes, KB Holden, D Mack. Missed policy opportunities to advance health equity: Missed policy opportunities to advance health equity by recording demographic data in electronic health records. Am J Public Health. 105: 2015; S380
10.2105/AJPH.2014.302384
PubMedWeb of Science®Google Scholar
[40]X Meng, C D'Arcy. Education and dementia in the context of the cognitive reserve hypothesis: A systematic review with meta-analyses and qualitative analyses. PLoS One. 7: 2012; e38268
10.1371/journal.pone.0038268
CASPubMedWeb of Science®Google Scholar
[41]M Baumgart, HM Snyder, MC Carrillo, S Fazio, H Kim, H Johns. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective. Alzheimers DemenT. 11: 2015; 718–726
10.1016/j.jalz.2015.05.016
PubMedWeb of Science®Google Scholar
[42]K Manton, X Gu, S Ukraintseva. Declining prevalence of dementia in the US elderly population. Adv Gerontol. 16: 2005; 30–37
CASPubMedGoogle Scholar
[43]M Prince, GC Ali, M Guerchet, AM Prina, E Albanese, YT Wu. Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimer's Res Ther. 8: 2016; 23
10.1186/s13195-016-0188-8
PubMedWeb of Science®Google Scholar
[44]KM Langa, EB Larson, JH Karlawish, DM Cutler, MU Kabeto, SY Kim, et al. Trends in the prevalence and mortality of cognitive impairment in the United States: Is there evidence of a compression of cognitive morbidity?. Alzheimer's Demen. 4: 2008; 134–144
10.1016/j.jalz.2008.01.001
PubMedWeb of Science®Google Scholar
[45]YT Wu, AS Beiser, MM Breteler, L Fratiglioni, C Helmer, HC Hendrie, et al. The changing prevalence and incidence of dementia over time–current evidence. Nature Rev Neurol. 13: 2017; 327
10.1038/nrneurol.2017.63
PubMedWeb of Science®Google Scholar

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Volume15, Issue1

January 2019

Pages 17-24

Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years

Abstract

Introduction

Methods

Results

Discussion

Supporting Information

References

Citing Literature

References

Information

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Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years

Abstract

Introduction

Methods

Results

Discussion

Supporting Information

References

Citing Literature

References

Related

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