Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease
Corresponding Author
Niklas Mattsson
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Corresponding author. Tel.: +46 46 171000; Fax: +46 46 222 4720.
Corresponding author. Tel.: +31 20 444 0816; Fax: +31 20 444 0816.
E-mail address: [email protected] (N.M.), [email protected] (R.O.)
Search for more papers by this authorColin Groot
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Search for more papers by this authorWillemijn J. Jansen
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorSusan M. Landau
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Search for more papers by this authorVictor L. Villemagne
Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia
Search for more papers by this authorSebastiaan Engelborghs
Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium
Search for more papers by this authorMark M. Mintun
Avid Radiopharmaceuticals, Philadelphia, PA, USA
Search for more papers by this authorAlberto Lleo
Neurology Department, Hospital de Sant Pau, Barcelona, Spain
Search for more papers by this authorJosé Luis Molinuevo
Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain
Search for more papers by this authorWilliam J. Jagust
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Search for more papers by this authorGiovanni B. Frisoni
Memory Clinic and LANVIE- Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Search for more papers by this authorAdrian Ivanoiu
Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium
Search for more papers by this authorGaël Chételat
Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France
Search for more papers by this authorCatarina Resende de Oliveira
Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Search for more papers by this authorKaren M. Rodrigue
Center for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA
Search for more papers by this authorJohannes Kornhuber
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen- Nuremberg, Erlangen, Germany
Search for more papers by this authorAnders Wallin
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden
Search for more papers by this authorAleksandra Klimkowicz-Mrowiec
Jagiellonian University College of Medicine, Krakow, Poland
Search for more papers by this authorRamesh Kandimalla
Department of Biochemistry, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Search for more papers by this authorJulius Popp
Department of Psychiatry, Service of Old Age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland
Search for more papers by this authorPauline P. Aalten
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorDag Aarsland
Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway
Search for more papers by this authorDaniel Alcolea
Neurology Department, Hospital de Sant Pau, Barcelona, Spain
Search for more papers by this authorIna S. Almdahl
Department of Neurology, Akershus University Hospital, Lørenskog, Norway
Search for more papers by this authorInês Baldeiras
Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Search for more papers by this authorMark A. van Buchem
Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorEnrica Cavedo
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
AXA Research Fund & UPMC Chair, Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Paris, France
Search for more papers by this authorAnn D. Cohen
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA
Search for more papers by this authorStefan Förster
Department of Nuclear Medicine, Technische Universitaet München, Munich, Germany
Search for more papers by this authorJuan Fortea
Neurology Department, Hospital de Sant Pau, Barcelona, Spain
Search for more papers by this authorKristian S. Frederiksen
Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorYvonne Freund-Levi
Department of Geriatrics, Karolinska University Hospital Huddinge, Section of Clinical Geriatrics, Institution of NVS, Karolinska Institutet, Stockholm, Sweden
Search for more papers by this authorKiran Dip Gill
Department of Biochemistry, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Search for more papers by this authorOlymbia Gkatzima
Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Search for more papers by this authorTimo Grimmer
Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich, Germany
Search for more papers by this authorHarald Hampel
AXA Research Fund & UPMC Chair, Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Paris, France
Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig-Maximilian University, Munich, Germany
Search for more papers by this authorSanna-Kaisa Herukka
Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
Search for more papers by this authorPeter Johannsen
Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark
Search for more papers by this authorKoen van Laere
Department of Imaging and Pathology, Catholic University Leuven, Leuven, Belgium
Search for more papers by this authorMony J. de Leon
School of Medicine, Center for Brain Health, New York University, New York, NY, USA
Search for more papers by this authorWolfgang Maier
Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Search for more papers by this authorJan Marcusson
Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden
Search for more papers by this authorOlga Meulenbroek
Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Search for more papers by this authorHanne M. Møllergård
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA
Search for more papers by this authorJohn C. Morris
Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Search for more papers by this authorBarbara Mroczko
Department of Neurodegeneration Diagnostics, Leading National Research Centre in Białystok (KNOW), Medical University of Białystok, Białystok, Poland
Search for more papers by this authorArto Nordlund
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden
Search for more papers by this authorSudesh Prabhakar
Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Search for more papers by this authorOliver Peters
Department of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Search for more papers by this authorLorena Rami
Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain
Search for more papers by this authorEloy Rodríguez-Rodríguez
Neurology Service, Universitary Hospital Marqués de Valdecilla, CIBERNED, IDIVAL, Santander, Spain
Search for more papers by this authorCatherine M. Roe
Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Search for more papers by this authorEckart Rüther
Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany
Search for more papers by this authorIsabel Santana
Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Search for more papers by this authorJohannes Schröder
Sektion Gerontopsychiatrie, Universität Heidelberg, Heidelberg, Germany
Search for more papers by this authorSang W. Seo
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Search for more papers by this authorHilkka Soininen
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorLuiza Spiru
Department of Geriatrics-Gerontology-Gerontopsychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Search for more papers by this authorErik Stomrud
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Search for more papers by this authorHanne Struyfs
Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium
Search for more papers by this authorCharlotte E. Teunissen
Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands
Search for more papers by this authorFrans R.J. Verhey
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorStephanie J.B. Vos
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorLinda J.C. van Waalwijk van Doorn
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Search for more papers by this authorGunhild Waldemar
Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorÅsa K. Wallin
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Search for more papers by this authorJens Wiltfang
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen- Nuremberg, Erlangen, Germany
Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany
Search for more papers by this authorRik Vandenberghe
Laboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven, Belgium
Search for more papers by this authorDavid J. Brooks
Division of Neuroscience, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK
Search for more papers by this authorTormod Fladby
Department of Neurology, Akershus University Hospital, Lørenskog, Norway
Search for more papers by this authorChristopher C. Rowe
Department of Nuclear Medicine, Technische Universitaet München, Munich, Germany
Search for more papers by this authorAlexander Drzezga
Department of Nuclear Medicine, University of Cologne, Cologne, Germany
Search for more papers by this authorMarcel M. Verbeek
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Search for more papers by this authorMarie Sarazin
Neurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Search for more papers by this authorDavid A. Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorAdam S. Fleisher
Department of Neurology, Akershus University Hospital, Lørenskog, Norway
Eli Lilly, Indianapolis, IN, USA
Department of Neurosciences, University of California, San Diego, CA, USA
Search for more papers by this authorWilliam E. Klunk
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA
Search for more papers by this authorDuk L. Na
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorPascual Sánchez-Juan
Neurology Service, Universitary Hospital Marqués de Valdecilla, CIBERNED, IDIVAL, Santander, Spain
Search for more papers by this authorDong Young Lee
Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, South Korea
Search for more papers by this authorAgneta Nordberg
Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet and Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorMagda Tsolaki
Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Search for more papers by this authorVincent Camus
CHRU de Tours, CIC INSERM 1415, INSERM U930, Université François Rabelais de Tours, Tours, France
Search for more papers by this authorJuha O. Rinne
Turku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku, Finland
Search for more papers by this authorAnne M. Fagan
Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Search for more papers by this authorHenrik Zetterberg
Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK
UK Dementia Research Institute, London, UK
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden
Sweden and Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
Search for more papers by this authorKaj Blennow
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden
Sweden and Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
Search for more papers by this authorGil D. Rabinovici
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA
Search for more papers by this authorOskar Hansson
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Search for more papers by this authorBart N.M. van Berckel
Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Search for more papers by this authorWiesje M. van der Flier
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands
Search for more papers by this authorPhilip Scheltens
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Search for more papers by this authorPieter Jelle Visser
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorCorresponding Author
Rik Ossenkoppele
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Corresponding author. Tel.: +46 46 171000; Fax: +46 46 222 4720.
Corresponding author. Tel.: +31 20 444 0816; Fax: +31 20 444 0816.
E-mail address: [email protected] (N.M.), [email protected] (R.O.)
Search for more papers by this authorCorresponding Author
Niklas Mattsson
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Corresponding author. Tel.: +46 46 171000; Fax: +46 46 222 4720.
Corresponding author. Tel.: +31 20 444 0816; Fax: +31 20 444 0816.
E-mail address: [email protected] (N.M.), [email protected] (R.O.)
Search for more papers by this authorColin Groot
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Search for more papers by this authorWillemijn J. Jansen
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorSusan M. Landau
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Search for more papers by this authorVictor L. Villemagne
Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia
Search for more papers by this authorSebastiaan Engelborghs
Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium
Search for more papers by this authorMark M. Mintun
Avid Radiopharmaceuticals, Philadelphia, PA, USA
Search for more papers by this authorAlberto Lleo
Neurology Department, Hospital de Sant Pau, Barcelona, Spain
Search for more papers by this authorJosé Luis Molinuevo
Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain
Search for more papers by this authorWilliam J. Jagust
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Search for more papers by this authorGiovanni B. Frisoni
Memory Clinic and LANVIE- Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Search for more papers by this authorAdrian Ivanoiu
Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium
Search for more papers by this authorGaël Chételat
Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France
Search for more papers by this authorCatarina Resende de Oliveira
Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Search for more papers by this authorKaren M. Rodrigue
Center for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA
Search for more papers by this authorJohannes Kornhuber
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen- Nuremberg, Erlangen, Germany
Search for more papers by this authorAnders Wallin
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden
Search for more papers by this authorAleksandra Klimkowicz-Mrowiec
Jagiellonian University College of Medicine, Krakow, Poland
Search for more papers by this authorRamesh Kandimalla
Department of Biochemistry, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Search for more papers by this authorJulius Popp
Department of Psychiatry, Service of Old Age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland
Search for more papers by this authorPauline P. Aalten
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorDag Aarsland
Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway
Search for more papers by this authorDaniel Alcolea
Neurology Department, Hospital de Sant Pau, Barcelona, Spain
Search for more papers by this authorIna S. Almdahl
Department of Neurology, Akershus University Hospital, Lørenskog, Norway
Search for more papers by this authorInês Baldeiras
Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Search for more papers by this authorMark A. van Buchem
Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorEnrica Cavedo
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
AXA Research Fund & UPMC Chair, Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Paris, France
Search for more papers by this authorAnn D. Cohen
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA
Search for more papers by this authorStefan Förster
Department of Nuclear Medicine, Technische Universitaet München, Munich, Germany
Search for more papers by this authorJuan Fortea
Neurology Department, Hospital de Sant Pau, Barcelona, Spain
Search for more papers by this authorKristian S. Frederiksen
Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorYvonne Freund-Levi
Department of Geriatrics, Karolinska University Hospital Huddinge, Section of Clinical Geriatrics, Institution of NVS, Karolinska Institutet, Stockholm, Sweden
Search for more papers by this authorKiran Dip Gill
Department of Biochemistry, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Search for more papers by this authorOlymbia Gkatzima
Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Search for more papers by this authorTimo Grimmer
Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich, Germany
Search for more papers by this authorHarald Hampel
AXA Research Fund & UPMC Chair, Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Paris, France
Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig-Maximilian University, Munich, Germany
Search for more papers by this authorSanna-Kaisa Herukka
Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
Search for more papers by this authorPeter Johannsen
Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark
Search for more papers by this authorKoen van Laere
Department of Imaging and Pathology, Catholic University Leuven, Leuven, Belgium
Search for more papers by this authorMony J. de Leon
School of Medicine, Center for Brain Health, New York University, New York, NY, USA
Search for more papers by this authorWolfgang Maier
Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Search for more papers by this authorJan Marcusson
Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden
Search for more papers by this authorOlga Meulenbroek
Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Search for more papers by this authorHanne M. Møllergård
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA
Search for more papers by this authorJohn C. Morris
Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Search for more papers by this authorBarbara Mroczko
Department of Neurodegeneration Diagnostics, Leading National Research Centre in Białystok (KNOW), Medical University of Białystok, Białystok, Poland
Search for more papers by this authorArto Nordlund
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden
Search for more papers by this authorSudesh Prabhakar
Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Search for more papers by this authorOliver Peters
Department of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Search for more papers by this authorLorena Rami
Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain
Search for more papers by this authorEloy Rodríguez-Rodríguez
Neurology Service, Universitary Hospital Marqués de Valdecilla, CIBERNED, IDIVAL, Santander, Spain
Search for more papers by this authorCatherine M. Roe
Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Search for more papers by this authorEckart Rüther
Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany
Search for more papers by this authorIsabel Santana
Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Search for more papers by this authorJohannes Schröder
Sektion Gerontopsychiatrie, Universität Heidelberg, Heidelberg, Germany
Search for more papers by this authorSang W. Seo
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Search for more papers by this authorHilkka Soininen
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorLuiza Spiru
Department of Geriatrics-Gerontology-Gerontopsychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Search for more papers by this authorErik Stomrud
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Search for more papers by this authorHanne Struyfs
Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium
Search for more papers by this authorCharlotte E. Teunissen
Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands
Search for more papers by this authorFrans R.J. Verhey
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorStephanie J.B. Vos
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorLinda J.C. van Waalwijk van Doorn
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Search for more papers by this authorGunhild Waldemar
Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorÅsa K. Wallin
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Search for more papers by this authorJens Wiltfang
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen- Nuremberg, Erlangen, Germany
Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany
Search for more papers by this authorRik Vandenberghe
Laboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven, Belgium
Search for more papers by this authorDavid J. Brooks
Division of Neuroscience, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK
Search for more papers by this authorTormod Fladby
Department of Neurology, Akershus University Hospital, Lørenskog, Norway
Search for more papers by this authorChristopher C. Rowe
Department of Nuclear Medicine, Technische Universitaet München, Munich, Germany
Search for more papers by this authorAlexander Drzezga
Department of Nuclear Medicine, University of Cologne, Cologne, Germany
Search for more papers by this authorMarcel M. Verbeek
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands
Search for more papers by this authorMarie Sarazin
Neurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Search for more papers by this authorDavid A. Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Search for more papers by this authorAdam S. Fleisher
Department of Neurology, Akershus University Hospital, Lørenskog, Norway
Eli Lilly, Indianapolis, IN, USA
Department of Neurosciences, University of California, San Diego, CA, USA
Search for more papers by this authorWilliam E. Klunk
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA
Search for more papers by this authorDuk L. Na
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorPascual Sánchez-Juan
Neurology Service, Universitary Hospital Marqués de Valdecilla, CIBERNED, IDIVAL, Santander, Spain
Search for more papers by this authorDong Young Lee
Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, South Korea
Search for more papers by this authorAgneta Nordberg
Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet and Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorMagda Tsolaki
Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Search for more papers by this authorVincent Camus
CHRU de Tours, CIC INSERM 1415, INSERM U930, Université François Rabelais de Tours, Tours, France
Search for more papers by this authorJuha O. Rinne
Turku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku, Finland
Search for more papers by this authorAnne M. Fagan
Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Search for more papers by this authorHenrik Zetterberg
Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK
UK Dementia Research Institute, London, UK
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden
Sweden and Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
Search for more papers by this authorKaj Blennow
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden
Sweden and Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
Search for more papers by this authorGil D. Rabinovici
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA
Search for more papers by this authorOskar Hansson
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Search for more papers by this authorBart N.M. van Berckel
Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Search for more papers by this authorWiesje M. van der Flier
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands
Search for more papers by this authorPhilip Scheltens
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Search for more papers by this authorPieter Jelle Visser
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
Search for more papers by this authorCorresponding Author
Rik Ossenkoppele
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
Corresponding author. Tel.: +46 46 171000; Fax: +46 46 222 4720.
Corresponding author. Tel.: +31 20 444 0816; Fax: +31 20 444 0816.
E-mail address: [email protected] (N.M.), [email protected] (R.O.)
Search for more papers by this authorAbstract
Introduction
Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology.
Methods
We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location.
Results
The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education.
Discussion
The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.
Supporting Information
Filename | Description |
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alzjjalz201802009-sup-0001.jpgapplication/jpg, 380 KB | Supplemental Fig. S1 |
alzjjalz201802009-sup-0002.jpgapplication/jpg, 212.2 KB | Supplemental Fig. S2 |
alzjjalz201802009-sup-0003.jpgapplication/jpg, 480.6 KB | Supplemental Fig. S3 |
alzjjalz201802009-sup-0004.docxapplication/docx, 97.1 KB | Supplemental Tables 1–6 and Legends for Supplemental Figures S1–S3 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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