Sugary beverage intake and preclinical Alzheimer's disease in the community
Corresponding Author
Matthew P. Pase
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia
Corresponding author. Tel.: +1-617-638-8064.
E-mail address: [email protected]
Search for more papers by this authorJayandra J. Himali
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Search for more papers by this authorPaul F. Jacques
Framingham Heart Study, Framingham, MA, USA
Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Search for more papers by this authorCharles DeCarli
Framingham Heart Study, Framingham, MA, USA
Department of Neurology, School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento, CA, USA
Search for more papers by this authorClaudia L. Satizabal
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Search for more papers by this authorHugo Aparicio
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Search for more papers by this authorRamachandran S. Vasan
Framingham Heart Study, Framingham, MA, USA
Sections of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Search for more papers by this authorAlexa S. Beiser
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Search for more papers by this authorSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Search for more papers by this authorCorresponding Author
Matthew P. Pase
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia
Corresponding author. Tel.: +1-617-638-8064.
E-mail address: [email protected]
Search for more papers by this authorJayandra J. Himali
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Search for more papers by this authorPaul F. Jacques
Framingham Heart Study, Framingham, MA, USA
Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Search for more papers by this authorCharles DeCarli
Framingham Heart Study, Framingham, MA, USA
Department of Neurology, School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento, CA, USA
Search for more papers by this authorClaudia L. Satizabal
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Search for more papers by this authorHugo Aparicio
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Search for more papers by this authorRamachandran S. Vasan
Framingham Heart Study, Framingham, MA, USA
Sections of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Search for more papers by this authorAlexa S. Beiser
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Search for more papers by this authorSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
Search for more papers by this authorAbstract
Introduction
Excess sugar consumption has been linked with Alzheimer's disease (AD) pathology in animal models.
Methods
We examined the cross-sectional association of sugary beverage consumption with neuropsychological (N = 4276) and magnetic resonance imaging (N = 3846) markers of preclinical Alzheimer's disease and vascular brain injury (VBI) in the community-based Framingham Heart Study. Intake of sugary beverages was estimated using a food frequency questionnaire.
Results
Relative to consuming less than one sugary beverage per day, higher intake of sugary beverages was associated with lower total brain volume (1–2/day, β ± standard error [SE] = −0.55 ± 0.14 mean percent difference, P = .0002; >2/day, β ± SE = −0.68 ± 0.18, P < .0001), and poorer performance on tests of episodic memory (all P < .01). Daily fruit juice intake was associated with lower total brain volume, hippocampal volume, and poorer episodic memory (all P < .05). Sugary beverage intake was not associated with VBI in a consistent manner across outcomes.
Discussion
Higher intake of sugary beverages was associated cross-sectionally with markers of preclinical AD.
Supporting Information
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| alzjjalz201701024-sup-0001.docxapplication/docx, 26.2 KB | Supplemental Tables 1–4 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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