The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015
Corresponding Author
William J. Jagust
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Corresponding author. Tel.: +1-510-643-6537.
E-mail address: [email protected]
Search for more papers by this authorSusan M. Landau
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Search for more papers by this authorRobert A. Koeppe
Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA
Search for more papers by this authorChester A. Mathis
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
Search for more papers by this authorJulie C. Price
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
Search for more papers by this authorNorman L. Foster
Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA
Search for more papers by this authorAngela Y. Wang
Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA
Search for more papers by this authorCorresponding Author
William J. Jagust
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Corresponding author. Tel.: +1-510-643-6537.
E-mail address: [email protected]
Search for more papers by this authorSusan M. Landau
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Search for more papers by this authorRobert A. Koeppe
Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA
Search for more papers by this authorChester A. Mathis
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
Search for more papers by this authorJulie C. Price
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
Search for more papers by this authorNorman L. Foster
Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA
Search for more papers by this authorAngela Y. Wang
Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA
Search for more papers by this authorAbstract
Introduction
This article reviews the work done in the Alzheimer's Disease Neuroimaging Initiative positron emission tomography (ADNI PET) core over the past 5 years, largely concerning techniques, methods, and results related to amyloid imaging in ADNI.
Methods
The PET Core has used [18F]florbetapir routinely on ADNI participants, with over 1600 scans available for download. Four different laboratories are involved in data analysis, and have examined factors such as longitudinal florbetapir analysis, use of [18F]fluorodeoxyglucose (FDG)-PET in clinical trials, and relationships between different biomarkers and cognition.
Results
Converging evidence from the PET Core has indicated that cross-sectional and longitudinal florbetapir analyses require different reference regions. Studies have also examined the relationship between florbetapir data obtained immediately after injection, which reflects perfusion, and FDG-PET results. Finally, standardization has included the translation of florbetapir PET data to a centiloid scale.
Conclusion
The PET Core has demonstrated a variety of methods for the standardization of biomarkers such as florbetapir PET in a multicenter setting.
References
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