Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060)
Corresponding Author
Kumar B. Rajan
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA
Correspondence
Kumar B. Rajan, Rush Institute for Healthy Aging, Rush University Medical Center, 1700 W Van Buren St, Suite 245, Chicago, IL 60612.
E-mail: [email protected]
Search for more papers by this authorJennifer Weuve
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA
Search for more papers by this authorLisa L. Barnes
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorElizabeth A. McAninch
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorRobert S. Wilson
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorDenis A. Evans
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorCorresponding Author
Kumar B. Rajan
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA
Correspondence
Kumar B. Rajan, Rush Institute for Healthy Aging, Rush University Medical Center, 1700 W Van Buren St, Suite 245, Chicago, IL 60612.
E-mail: [email protected]
Search for more papers by this authorJennifer Weuve
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA
Search for more papers by this authorLisa L. Barnes
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorElizabeth A. McAninch
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorRobert S. Wilson
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorDenis A. Evans
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorAbstract
Introduction
The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.
Methods
We estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores.
Results
The 2020 US Census–adjusted prevalence of clinical AD was 11.3% (95% confidence interval [CI] = 10.7–11.9): 10.0% among non-Hispanic Whites, 14.0% among Hispanics, and 18.6% among non-Hispanic Blacks. We estimate that in 2020, 6.07 (95% CI = 5.75–6.38) million people were living with clinical AD, which increases to 13.85 (95% CI = 12.98–14.74) million in 2060, 423% higher among Hispanics, 192% higher among Blacks, and 63% higher among Whites. However, there are predicted to be more significant increases in later years among those over 85 and women compared to men.
Discussion
The number of people with clinical AD will increase as the “baby boom” generation reaches older ages, exerting a strong upward influence on disease burden.
CONFLICTS OF INTEREST
The authors have no conflicts of interest to report.
Open Research
DATA AVAILABILITY STATEMENT
De-identified data are available on request for qualified investigators from www.riha.rush.edu/dataportal.html.
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