Unhealthy foods may attenuate the beneficial relation of a Mediterranean diet to cognitive decline
Corresponding Author
Puja Agarwal
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Correspondence
Puja Agarwal, Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, 1700 W Van Buren, Chicago, IL, USA.
Email: [email protected]
Search for more papers by this authorKlodian Dhana
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorLisa L. Barnes
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorThomas M Holland
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorYanyu Zhang
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorDenis A. Evans
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorMartha Clare Morris
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Deceased
Search for more papers by this authorCorresponding Author
Puja Agarwal
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Correspondence
Puja Agarwal, Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, 1700 W Van Buren, Chicago, IL, USA.
Email: [email protected]
Search for more papers by this authorKlodian Dhana
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorLisa L. Barnes
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorThomas M Holland
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorYanyu Zhang
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorDenis A. Evans
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Search for more papers by this authorMartha Clare Morris
Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA
Deceased
Search for more papers by this authorAbstract
Introduction
It is unclear whether eating Western diet food components offsets the Mediterranean diet's (MedDiet) potential benefits on cognitive decline.
Methods
The study includes 5001 Chicago Health and Aging Project participants (63% African American, 36% males, 74 ± 6.0 years old), with food frequency questionnaires and ≥ two cognitive assessments over 6.3 ± 2.8 years of follow-up. Mixed-effects models were adjusted for age, sex, education, race, cognitive activities, physical activity, and total calories.
Results
Stratified analysis showed a significant effect of higher MedDiet on cognitive decline only with a low Western diet score (highest vs lowest MedDiet tertile: β = 0.020, P = .002; p trend = 0.002) and not with a high Western diet score (highest vs lowest MedDiet tertile: β = 0.010, P = .11; p trend = 0.09).
Conclusion
This prospective study found that high consumption of Western diet components attenuates benefits of the MedDiet on cognition.
CONFLICT OF INTEREST
None.
Supporting Information
| Filename | Description |
|---|---|
| alz12277-sup-0001-figureS1.docx206.4 KB | Supplementary Figure 1: Path diagram for two-factor analysis. Factor 2 represents the Western dietary pattern |
| alz12277-sup-0002-TableS1-S5.docx32.6 KB | Supplementary Table 1: Baseline characteristics of Analytical sample (n = 5001) and Overall cohort (n = 10,802) Chicago Health and Aging Project Supplementary Table 2: Mediterranean diet (MedDiet) components and scoring matrix Supplementary Table 3: Factor Loadings of the two significant factors - Healthy diet pattern and Western diet pattern identified using principal component analysis Supplementary Table 4: Baseline characteristics of the study population as per low and high Western diet group Supplementary Table 5: Mediterranean dietary components by tertile of MedDiet in low and high Western diet group |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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