Volume 17, Issue 5 p. 847-855

Utility of MRI in the identification of hippocampal sclerosis of aging

Davis C. Woodworth,

Davis C. Woodworth

Department of Neurology, University of California, Orange, California, USA

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA

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Hannah L. Nguyen,

Hannah L. Nguyen

Department of Biological Sciences, University of California, Irvine, California, USA

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Zainab Khan,

Zainab Khan

Department of Biological Sciences, University of California, Irvine, California, USA

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Claudia H. Kawas,

Claudia H. Kawas

Department of Neurology, University of California, Orange, California, USA

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA

Department of Neurobiology and Behavior, University of California, Irvine, California, USA

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María M. Corrada,

María M. Corrada

Department of Neurology, University of California, Orange, California, USA

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA

Department of Neurobiology and Behavior, University of California, Irvine, California, USA

Department of Epidemiology, University of California, Irvine, California, USA

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S. Ahmad Sajjadi,

Corresponding Author

S. Ahmad Sajjadi

[email protected]

Department of Neurology, University of California, Orange, California, USA

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA

Correspondence

S. Ahmad Sajjadi, Office 364, Med Surge II, Academy Way, Irvine, CA, 92697, USA.

E-mail: [email protected]

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Davis C. Woodworth,

Davis C. Woodworth

Department of Neurology, University of California, Orange, California, USA

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA

Search for more papers by this author

Hannah L. Nguyen,

Hannah L. Nguyen

Department of Biological Sciences, University of California, Irvine, California, USA

Search for more papers by this author

Zainab Khan,

Zainab Khan

Department of Biological Sciences, University of California, Irvine, California, USA

Search for more papers by this author

Claudia H. Kawas,

Claudia H. Kawas

Department of Neurology, University of California, Orange, California, USA

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA

Department of Neurobiology and Behavior, University of California, Irvine, California, USA

Search for more papers by this author

María M. Corrada,

María M. Corrada

Department of Neurology, University of California, Orange, California, USA

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA

Department of Neurobiology and Behavior, University of California, Irvine, California, USA

Department of Epidemiology, University of California, Irvine, California, USA

Search for more papers by this author

S. Ahmad Sajjadi,

Corresponding Author

S. Ahmad Sajjadi

[email protected]

Department of Neurology, University of California, Orange, California, USA

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA

Correspondence

S. Ahmad Sajjadi, Office 364, Med Surge II, Academy Way, Irvine, CA, 92697, USA.

E-mail: [email protected]

Search for more papers by this author

First published: 07 December 2020

https://doi.org/10.1002/alz.12241

Citations: 9

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Abstract

Introduction

Hippocampal sclerosis of aging (HS) is a common pathology often misdiagnosed as Alzheimer's disease. We tested the hypothesis that participants with HS would have a magnetic resonance imaging (MRI)-detectable hippocampal pattern of atrophy distinct from participants without HS, both with and without Alzheimer's disease neuropathology (ADNP).

Methods

Query of the National Alzheimer's Coordinating Center database identified 198 participants with MRI and autopsy. Hippocampal subfields were segmented with FreeSurfer v6. Analysis of covariance for subfield volumes compared HS+ participants to those without HS, both with ADNP (HS–/ADNP+) and without (HS–/ADNP–).

Results

HS+ participants (N = 27, 14%) showed atrophied cornu ammonis 1 (CA1; left P < .001, η_p²= 0.14; right P = .001, η_p²= 0.09) and subiculum (left P < .001, η_p²= 0.139; right P = .001, η_p²= 0.085) compared to HS–/ADNP+ (N = 100, 51%). Compared to HS–/ADNP– (N = 71, 36%), HS+ also had atrophy in subiculum (left P < .001, η_p²= 0.235; right P = .002, η_p²= 0.137) and CA1 (left P < .001, η_p²= 0.137; right P = .006, η_p²= 0.070).

Discussion

Subiculum and CA1 atrophy from clinical MRI may be a promising in vivo biomarker for HS.

Supporting Information

REFERENCES

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Citing Literature

Volume17, Issue5

May 2021

Pages 847-855

Filename	Description
alz12241-sup-0001-SuppMat.docx27.4 KB	Supporting Information
alz12241-sup-0002-figureS1.docx180.1 KB	Supporting Information
alz12241-sup-0003-figureS2.docx386.6 KB	Supporting Information
alz12241-sup-0004-figureS3.docx230.1 KB	Supporting Information
alz12241-sup-0005-tableS1.docx29.2 KB	Supporting Information
alz12241-sup-0006-tableS2.docx29.5 KB	Supporting Information
alz12241-sup-0007-tableS3.docx29.3 KB	Supporting Information
alz12241-sup-0008-tableS4.docx29.3 KB	Supporting Information

Utility of MRI in the identification of hippocampal sclerosis of aging

Abstract

Introduction

Methods

Results

Discussion

Supporting Information

REFERENCES

Citing Literature

References

Information

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Utility of MRI in the identification of hippocampal sclerosis of aging

Abstract

Introduction

Methods

Results

Discussion

Supporting Information

REFERENCES

Citing Literature

References

Related

Information