Volume 17, Issue 3 p. 407-416
FEATURED ARTICLE

Blood polyunsaturated omega-3 fatty acids, brain atrophy, cognitive decline, and dementia risk

Aline Thomas

Corresponding Author

Aline Thomas

INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000 France

Correspondence

Aline Thomas, Inserm U1219, ISPED, Univ. Bordeaux, CS 61292, 146 rue Léo-Saignat, F-33076 Bordeaux cedex, France.

Email: [email protected]

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Marion Baillet

Marion Baillet

INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000 France

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Cécile Proust-Lima

Cécile Proust-Lima

INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000 France

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Catherine Féart

Catherine Féart

INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000 France

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Alexandra Foubert-Samier

Alexandra Foubert-Samier

INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000 France

Institut des Maladies Neurodégénératives, Bordeaux Univ. Hospital, Bordeaux, F-33000 France

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Catherine Helmer

Catherine Helmer

INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000 France

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Gwénaëlle Catheline

Gwénaëlle Catheline

CNRS, INCIA, UMR5287, Univ. Bordeaux, Bordeaux, F-33000 France

Laboratoire Neuroimagerie et vie quotidienne, EPHE-PSL, Bordeaux, F-33000 France

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Cécilia Samieri

Cécilia Samieri

INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000 France

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First published: 08 October 2020
Citations: 23

Abstract

Introduction

We searched for consistent associations of an omega-3 index in plasma (sum of eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) with several dementia-related outcomes in a large cohort of older adults.

Methods

We included 1279 participants from the Three-City study, non-demented at the time of blood measurements at baseline, with face-to-face neuropsychological assessment and systematic detection of incident dementia over a 17-year follow-up. An ancillary study included 467 participants with up to three repeated brain imaging exams over 10 years.

Results

In multivariable models, higher levels of plasma EPA+DHA were consistently associated with a lower risk of dementia (hazard ratio for 1 standard deviation = 0.87 [95% confidence interval, 0.76–0.98]), and a lower decline in global cognition (= .04 for change over time), memory (= .06), and medial temporal lobe volume (= .02).

Discussion

This prospective study provides compelling evidence for a relationship between long-chain omega-3 fatty acids levels and lower risks for dementia and related outcomes.

CONFLICTS OF INTEREST

A. Thomas, M. Baillet, C. Proust-Lima, C. Helmer, G. Catheline, and C. Samieri report no conflicts of interest. A. Foubert-Samier received fees from LVL medical. C. Féart received fees for conferences from Danone Research and Nutricia.